Determinants of hypoventilation during wakefulness and sleep in diaphragmatic paralysis

J. Skatrud, C. Iber, W. McHugh

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

A 45-yr-old man with limb girdle muscular dystrophy, bilateral diaphragmatic paralysis, chronic carbon dioxide retention, and hypersomnolence was studied to determine the causes of hypoventilation during wakefulness and during sleep. Awake hypoventilation was associated with an insufficient inspiratory effort in the presence of inefficient respiratory muscles and a shortened inspiratory time. During sleep, severe hypoventilation and oxygen desaturation occurred only during REM-induced intercostal and accessory muscle inhibition.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume121
Issue number3
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint Dive into the research topics of 'Determinants of hypoventilation during wakefulness and sleep in diaphragmatic paralysis'. Together they form a unique fingerprint.

Cite this