Determination of arterial compliance using blood pressure waveform analysis with the CR-2000 system: Reliability, repeatability, and establishment of normal values for healthy European population - The Seven European Sites Study (SESS)

Reuven Zimlichman, Marina Shargorodsky, Mona Boaz, Daniel Duprez, Karl Heintz Rahn, Damiano Rizzoni, Antonio Coca Payeras, Christian Hamm, Gary McVeigh

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

We determined the reliability and repeatability of measurements of arterial compliance (AC) and gender- and age-specific normal ranges for a healthy European population. Three hundred eight healthy volunteers from seven sites were evaluated. Two measurements were taken during the first visit, repeated on a second visit 1 to 4 weeks later. We used the HDI/PulseWave CR-2000 for measurements of AC. Intravisit measurements, taken 5 min apart, differed by less than 3% (range, 0.36% to 2.97%). All intervisit measures differed by less than 4% (range, 0.24% to 3.67%); none of these differences was statistically significant. All correlation coefficients for pairs of AC parameters measured 5 min apart at the same visit were significant at P < .0001. Paired AC parameters at visit 1 and 2 were highly correlated (P < .0001). Repeated measures GLM (general linear model) failed to detect a significant association between either of the AC parameters and visit (first or second), time (first or second measure at the same visit), and visit-by-time (the interaction of the two preceding factors), suggesting that order of measure had no effect on the final value. Analysis of reliability was used to develop a strictly parallel model estimate of unbiased reliability. Both intravisit and intervisit estimates of reliability indicate good repeatability of measure and were significant (P < .0001). The AC values were found to differ significantly by age group, with an inverse association between each of the AC parameters and age group. Measurement of the arterial waveform with the CR-2000 system is highly reproducible in healthy subjects.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalAmerican journal of hypertension
Volume18
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Arterial compliance
  • arterial pulsewave contour
  • normal range
  • reliability
  • repeatability

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