@inbook{b46c082307d249e786b8e6468904cec8,
title = "Determination of erythrocyte fragility as a marker of pesticide-induced membrane oxidative damage",
abstract = "Erythrocytes are readily available cells and a good model system to study the health status of individuals with pathologic complications. It can also serve as a meaningful target to study toxicant/xenobioticinduced damages. We have prepared different concentrations of a carbamate pesticide (carbofuran) and carried out experiments to determine its toxicity on erythrocytes in terms of mean erythrocyte fragility (MEF). We observed a significant alteration in the osmotic fragility upon treatment with carbofuran. In our earlier studies we have observed a good correlation between OF and OS in diabetic subjects. Study reveals OF as a potential biomarker of oxidative membrane damage in pathologic conditions as well as toxicant/xenobiotic/pesticide-induced oxidative membrane damage to erythrocytes.",
keywords = "Diabetes, Erythrocyte, Osmotic fragility, Xenobiotics",
author = "Bechan Sharma and Rai, {Devendra K.} and Rai, {Prashant Kumar} and Rizvi, {S. I.} and Geeta Watal",
year = "2010",
doi = "10.1007/978-1-60761-411-1_8",
language = "English (US)",
isbn = "9781607614104",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "123--128",
booktitle = "Advanced Protocols in Oxidative Stress II",
}
