TY - JOUR
T1 - Developing a Clinico-Molecular Test for Individualized Treatment of Ovarian Cancer
T2 - The interplay of Precision Medicine Informatics with Clinical and Health Economics Dimensions
AU - Winterhoff, Boris J
AU - Kommoss, Stefan
AU - Heitz, Florian
AU - Konecny, Gottfried E.
AU - Dowdy, Sean C.
AU - Mullany, Sally A
AU - Park-Simon, Tjoung Won
AU - Baumann, Klaus
AU - Hilpert, Felix
AU - Brucker, Sara
AU - du Bois, Andreas
AU - Schröder, Willibald
AU - Burges, Alexander
AU - Shen, Steven
AU - Wang, Jinhua
AU - Tourani, Roshan
AU - Ma, Sisi
AU - Pfisterer, Jacobus
AU - Aliferis, MD, PhD, Constantin
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We report recent progress in the development of a precision test for individualized use of the VEGF-A targeting drug bevacizumab for treating ovarian cancer. We discuss the discovery model stage (i.e., past feasibility modeling and before conversion to the production test). Main results: (a) Informatics modeling plays a critical role in supporting driving clinical and health economic requirements. (b) The novel computational models support the creation of a precision test with sufficient predictivity to reduce healthcare system costs up to $30 billion over 10 years, and make the use of bevacizumab affordable without loss of length or quality of life.
AB - We report recent progress in the development of a precision test for individualized use of the VEGF-A targeting drug bevacizumab for treating ovarian cancer. We discuss the discovery model stage (i.e., past feasibility modeling and before conversion to the production test). Main results: (a) Informatics modeling plays a critical role in supporting driving clinical and health economic requirements. (b) The novel computational models support the creation of a precision test with sufficient predictivity to reduce healthcare system costs up to $30 billion over 10 years, and make the use of bevacizumab affordable without loss of length or quality of life.
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M3 - Article
C2 - 30815151
SN - 1559-4076
VL - 2018
SP - 1093
EP - 1102
JO - AMIA ... Annual Symposium proceedings. AMIA Symposium
JF - AMIA ... Annual Symposium proceedings. AMIA Symposium
ER -
