TY - JOUR
T1 - Developing an HIV cytotoxic T-lymphocyte vaccine
T2 - Issues of CD8 T-cell quantity, quality and location
AU - Masopust, D.
PY - 2009/1
Y1 - 2009/1
N2 - Abstract. Masopust D (University of Minnesota, Minneapolis, MN, USA). Developing an HIV cytotoxic T-lymphocyte vaccine: issues of CD8 T-cell quantity, quality and location (Review). J Intern Med 2008; 265: 125-137. Issues of quantity, quality and location impact the ability of CD8 T cells to mediate protection from infection. These issues are considered in light of human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) vaccination. Methods are reviewed that result in 100- to 1000-fold higher frequencies of vaccine-specific memory CD8 T cells than that achieved by current HIV/SIV vaccine approaches. Data demonstrating that location within mucosal tissues has a direct impact on memory CD8 T-cell function are discussed. Arguments are made that establishing memory CD8 T cells within mucosal sites of transmission, a priori to natural infection, may be essential for conferring optimal and rapid protection. Lastly, it is proposed that heterologous prime-boost vaccination with recombinant live replicating vectors, which has the potential to induce tremendous numbers of cytolytic memory CD8 T cells within mucosal tissues, would provide a far more stringent test of the hypothesis that memory CD8 T cells could, in principal, form the basis for a preventative HIV vaccine.
AB - Abstract. Masopust D (University of Minnesota, Minneapolis, MN, USA). Developing an HIV cytotoxic T-lymphocyte vaccine: issues of CD8 T-cell quantity, quality and location (Review). J Intern Med 2008; 265: 125-137. Issues of quantity, quality and location impact the ability of CD8 T cells to mediate protection from infection. These issues are considered in light of human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) vaccination. Methods are reviewed that result in 100- to 1000-fold higher frequencies of vaccine-specific memory CD8 T cells than that achieved by current HIV/SIV vaccine approaches. Data demonstrating that location within mucosal tissues has a direct impact on memory CD8 T-cell function are discussed. Arguments are made that establishing memory CD8 T cells within mucosal sites of transmission, a priori to natural infection, may be essential for conferring optimal and rapid protection. Lastly, it is proposed that heterologous prime-boost vaccination with recombinant live replicating vectors, which has the potential to induce tremendous numbers of cytolytic memory CD8 T cells within mucosal tissues, would provide a far more stringent test of the hypothesis that memory CD8 T cells could, in principal, form the basis for a preventative HIV vaccine.
KW - CD8
KW - CTL
KW - HIV
KW - Mucosa
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=57449085111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57449085111&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2796.2008.02054.x
DO - 10.1111/j.1365-2796.2008.02054.x
M3 - Article
C2 - 19093965
AN - SCOPUS:57449085111
SN - 0954-6820
VL - 265
SP - 125
EP - 137
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 1
ER -