TY - JOUR
T1 - Developing the science base for reducing tobacco harm
AU - Hatsukami, Dorothy
AU - Joseph, Anne
AU - LeSage, Mark
AU - Jensen, Joni
AU - Murphy, Sharon
AU - Pentel, Paul
AU - Kotlyar, Michael
AU - Borgida, Eugene
AU - Le, Chap
AU - Hecht, Stephen
PY - 2007/12
Y1 - 2007/12
N2 - The University of Minnesota Transdisciplinary Tobacco Use Research Center has been examining the multiple dimensions and the scientific evidence required to determine the feasibility of tobacco harm reduction as a means to reduce tobacco-related mortality and morbidity. Because of the complexity associated with exploring this area, an interdisciplinary approach is necessary. The research components that have been of particular focus at our center include (a) developing and validating biomarkers of tobacco-related exposure and toxicity, (b) developing animal models and designing studies with humans to assess a variety of smoking reduction approaches and potential reduced exposure products, and (c) determining individual differences in response to these interventions and products. A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future.
AB - The University of Minnesota Transdisciplinary Tobacco Use Research Center has been examining the multiple dimensions and the scientific evidence required to determine the feasibility of tobacco harm reduction as a means to reduce tobacco-related mortality and morbidity. Because of the complexity associated with exploring this area, an interdisciplinary approach is necessary. The research components that have been of particular focus at our center include (a) developing and validating biomarkers of tobacco-related exposure and toxicity, (b) developing animal models and designing studies with humans to assess a variety of smoking reduction approaches and potential reduced exposure products, and (c) determining individual differences in response to these interventions and products. A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future.
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U2 - 10.1080/14622200701679040
DO - 10.1080/14622200701679040
M3 - Review article
C2 - 18067031
AN - SCOPUS:37049021779
SN - 1462-2203
VL - 9
SP - 537
EP - 553
JO - Nicotine and Tobacco Research
JF - Nicotine and Tobacco Research
IS - SUPPL. 4
ER -