Development and applications of selective hydroesterification reactions

Carlton P. Folster, Robin P. Harkins, Shao Yu Lo, Janaya D. Sachs, Ian A. Tonks

Research output: Contribution to journalReview articlepeer-review

Abstract

The catalyzed addition of carbon monoxide to unsaturated compounds has drawn considerable attention over the past decade where more structurally complex molecules are made with high selectivities. In this review, we highlight some of the recent contributions that have significantly broadened the scope for the selective hydroesterification of alkenes and alkynes with alcohols to give esters. Key mechanistic features that drive linear or branched selectivity and how proper ligand choice plays an essential role are discussed. As a result, the utility for hydroesterification has expanded to new applications, which have also been highlighted.

Original languageEnglish (US)
Pages (from-to)469-484
Number of pages16
JournalTrends in Chemistry
Volume3
Issue number6
DOIs
StatePublished - Jun 2021

Bibliographical note

Funding Information:
The authors acknowledge support for writing this work from the US Department of Energy (DOE), Office of Science , Basic Energy Sciences (BES) under award DE-SC0020214 .

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

  • alkene
  • alkyne
  • carbonylation
  • catalysis
  • hydroesterification
  • selectivity

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