Development and characterization of a monoclonal antibody (Aby 6C6) that distinguishes medullary from cortical thymocytes.

D. R. Krawiec, C. C. Muscoplat

Research output: Contribution to journalArticlepeer-review

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Abstract

A hybridoma (6C6) producing antibodies with specificities to canine thymocyte surface antigens was produced using standard fusion techniques. The Aby 6C6 has affinity for medullary thymocytes, bone marrow cells, T- and B-peripheral lymphocytes, and monocytes. The Aby 6C6 appears to have 2 heavy chains with different molecular weights, an isoelectric focusing pattern consistent with monoclonality, and is an immunoglobulin G2b antibody with a kappa light chain.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalAmerican journal of veterinary research
Volume45
Issue number3
StatePublished - Mar 1 1984

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