Development and characterization of improved tissue engineered valve-equivalents using chemical and mechanical signaling

Michael R. Neidert, Jeremiah J. Wille, Robert T. Tranquillo

Research output: Contribution to journalConference articlepeer-review

Abstract

Tissue engineered valves hold considerable promise as replacement valves that avoid many of the problems present in current replacement valve technology. Furthermore, these valves, as a living construct, would be able to grow and remodel in vivo. We have developed a bileaflet biopolymer-scaffold based valve equivalent that possesses the correct geometry and underlying collagen fibril alignment. These valve-equivalents, however, have significantly worse mechanical properties as compared to healthy, native valves (in terms of ultimate tensile stress and tangent modulus). Furthermore, valve equivalents with initial collagen scaffolds show very little compositional remodeling leaving a predominantly collagen valve with little of the elastin and proteoglycan content present in native valves. We present work here aimed at improving the compositional and mechanical properties of valve-equivalents (VEs) by using a combination of chemical signaling by using a fibrin (as opposed to collagen) scaffold incubated with TGF-β and insulin and mechanical signaling achieved by VE incubation in a bioreactor.

Original languageEnglish (US)
Pages (from-to)858-859
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Collagen
  • Heart valves
  • TGF-β
  • Tissue engineering

Fingerprint

Dive into the research topics of 'Development and characterization of improved tissue engineered valve-equivalents using chemical and mechanical signaling'. Together they form a unique fingerprint.

Cite this