evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Dibyendu Dana; Shatarupa De; Pratikkumar Rathod; Anibal R. Davalos; Daniel A. Novoa; Suneeta Paroly; Viviana M. Torres; Nisar Afzal; Ravi S. Lankalapalli; Susan A. Rotenberg; Emmanuel J. Chang; Gopal Subramaniam; Sanjai Kumar

doi:10.1039/c4cc04037f

evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Dibyendu Dana, Shatarupa De, Pratikkumar Rathod, Anibal R. Davalos, Daniel A. Novoa, Suneeta Paroly, Viviana M. Torres, Nisar Afzal, Ravi S. Lankalapalli, Susan A. Rotenberg, Emmanuel J. Chang, Gopal Subramaniam, Sanjai Kumar

Medicinal Chemistry

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8 Scopus citations

Abstract

A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

Original language	English (US)
Pages (from-to)	10875-10878
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	74
DOIs	https://doi.org/10.1039/c4cc04037f
State	Published - Aug 18 2014

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Dana, D., De, S., Rathod, P., Davalos, A. R., Novoa, D. A., Paroly, S., Torres, V. M., Afzal, N., Lankalapalli, R. S., Rotenberg, S. A., Chang, E. J., Subramaniam, G., & Kumar, S. (2014). evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach. Chemical Communications, 50(74), 10875-10878. https://doi.org/10.1039/c4cc04037f

Dana, D, De, S, Rathod, P, Davalos, AR, Novoa, DA, Paroly, S, Torres, VM, Afzal, N, Lankalapalli, RS, Rotenberg, SA, Chang, EJ, Subramaniam, G & Kumar, S 2014, 'evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach', Chemical Communications, vol. 50, no. 74, pp. 10875-10878. https://doi.org/10.1039/c4cc04037f

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abstract = "A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.",

author = "Dibyendu Dana and Shatarupa De and Pratikkumar Rathod and Davalos, {Anibal R.} and Novoa, {Daniel A.} and Suneeta Paroly and Torres, {Viviana M.} and Nisar Afzal and Lankalapalli, {Ravi S.} and Rotenberg, {Susan A.} and Chang, {Emmanuel J.} and Gopal Subramaniam and Sanjai Kumar",

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AU - Rathod, Pratikkumar

AU - Davalos, Anibal R.

AU - Novoa, Daniel A.

AU - Paroly, Suneeta

AU - Torres, Viviana M.

AU - Afzal, Nisar

AU - Lankalapalli, Ravi S.

AU - Rotenberg, Susan A.

AU - Chang, Emmanuel J.

AU - Subramaniam, Gopal

AU - Kumar, Sanjai

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evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Abstract

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