Development of a vitreous substitute: Incorporating charges and fibrous structures in synthetic hydrogel materials

Svetlana Morozova; Paul Hamilton; Nathan Ravi; Murugappan Muthukumar

doi:10.1021/acs.macromol.6b00885

Development of a vitreous substitute: Incorporating charges and fibrous structures in synthetic hydrogel materials

Svetlana Morozova, Paul Hamilton, Nathan Ravi, Murugappan Muthukumar

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Synthetic hydrogel systems are promising long-term candidates for therapeutic use as vitreous substitutes. To improve the swelling and mechanical properties of existing synthetic substitutes for the natural vitreous, we incorporate charges and fibrous structures. Using dynamic light scattering, rheology, and swelling techniques we show in vitro that synthetic copolymers of methacrylic acid (MAA), methylacrylamide (MAm), and bismethacryloylcystamine (BMAC) cross-linked with gellan match the water content, transport properties, and dynamic response of the natural vitreous better than previously proposed synthetic substitutes.

Original language	English (US)
Pages (from-to)	4619-4626
Number of pages	8
Journal	Macromolecules
Volume	49
Issue number	12
DOIs	https://doi.org/10.1021/acs.macromol.6b00885
State	Published - Jun 28 2016

Bibliographical note

Funding Information:
Acknowledgment is made to the National Science Foundation (DMR-1504265) and AFOSR Grant N0. FA9550-14-1-0164. This work was also supported by the National Institute of Health Grant EY021620 and Core Grant P30EY02687 and Research to Prevent Blindness.

Publisher Copyright:
© 2016 American Chemical Society.

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AU - Muthukumar, Murugappan

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Development of a vitreous substitute: Incorporating charges and fibrous structures in synthetic hydrogel materials

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