Developmental changes in serum IGF-1 and IGFBP levels and liver IGFBP-3 mRNA expression in intrauterine growth-retarded and control swine

Kimberly A. Kampman, Timothy G. Ramsay, Michael E. White

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The 29 Mr x 10-3 IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 Mr x 10-3 IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 Mr x 10-3 IGFBP and IUGR in swine.

Original languageEnglish (US)
Pages (from-to)337-347
Number of pages11
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume108
Issue number3
DOIs
StatePublished - Jul 1994

Keywords

  • IGF
  • IGFBPS
  • IUGR swine

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