Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk

Howard H.F. Tang, Anna Lang, Shu Mei Teo, Louise M. Judd, Ronald Gangnon, Michael D Evans, Kristine E. Lee, Rose Vrtis, Patrick G. Holt, Robert F. Lemanske, Daniel J. Jackson, Kathryn E. Holt, Michael Inouye, James E. Gern

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma. Objectives: In this study, we tested whether developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses were related to risk of childhood asthma. Methods: Children participating in the Childhood Origins of Asthma study (N = 285) provided nasopharyngeal mucus samples in the first 2 years of life, during routine healthy study visits (at 2, 4, 6, 9, 12, 18, and 24 months of age), and during episodes of respiratory illnesses, all of which were analyzed for respiratory viruses and bacteria. We identified developmental trajectories of early-life microbiome composition, as well as predominant bacteria during respiratory illnesses, and we correlated these with presence of asthma at 6, 8, 11, 13, and 18 years of age. Results: Of the 4 microbiome trajectories identified, a Staphylococcus-dominant microbiome in the first 6 months of life was associated with increased risk of recurrent wheezing by age 3 years and asthma that persisted throughout childhood. In addition, this trajectory was associated with the early onset of allergic sensitization. During wheezing illnesses, detection of rhinoviruses and predominance of Moraxella were associated with asthma that persisted throughout later childhood. Conclusion: In infancy, the developmental composition of the microbiome during healthy periods and the predominant microbes during acute wheezing illnesses are both associated with the subsequent risk of developing persistent childhood asthma.

Original languageEnglish (US)
Pages (from-to)1683-1691
Number of pages9
JournalJournal of Allergy and Clinical Immunology
Volume147
Issue number5
DOIs
StatePublished - May 2021

Bibliographical note

Funding Information:
Supported by National Institutes of Health , National Heart, Lung, and Blood Institute (grant PO1 HL70381 ), the National Center for Advancing Translational Sciences (grant UL1TR000427 ), and the Office of the National Institutes of Health Director (grant no. UG3/UH3 OD023282 ). M.I. was supported by the Australian National Health and Medical Research Council (grant 1049539 ). H.H.F.T. was supported by an Australian National Health and Medical Research Council PhD scholarship. K.E.H. was supported by a Senior Medical Research Fellowship from the Viertel Foundation of Victoria.

Funding Information:
Supported by National Institutes of Health, National Heart, Lung, and Blood Institute (grant PO1 HL70381), the National Center for Advancing Translational Sciences (grant UL1TR000427), and the Office of the National Institutes of Health Director (grant no. UG3/UH3 OD023282). M.I. was supported by the Australian National Health and Medical Research Council (grant 1049539). H.H.F.T. was supported by an Australian National Health and Medical Research Council PhD scholarship. K.E.H. was supported by a Senior Medical Research Fellowship from the Viertel Foundation of Victoria.

Publisher Copyright:
© 2020 American Academy of Allergy, Asthma & Immunology

Keywords

  • asthma
  • birth cohort
  • children
  • development
  • Microbiome

PubMed: MeSH publication types

  • Journal Article

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