Developmental regression among children with autism spectrum disorder: Onset, duration, and effects on functional outcomes

Robin P. Goin-Kochel; Amy N. Esler; Stephen M. Kanne; Vanessa Hus

doi:10.1016/j.rasd.2014.04.002

Developmental regression among children with autism spectrum disorder: Onset, duration, and effects on functional outcomes

Robin P. Goin-Kochel, Amy N. Esler, Stephen M. Kanne, Vanessa Hus

Pediatrics - Neuropsychology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Studies using varied methods report that developmental regression occurs in a sizeable proportion of children with autism spectrum disorder (ASD). Findings are equivocal as to whether regression is associated with poorer cognitive and adaptive functioning. This study examined retrospective parent report in 2105 Simons Simplex Collection participants with ASD. Children were classified as having "full" or "subthreshold" losses on language and/or other skills using items from the Autism Diagnostic Interview-Revised (ADI-R) and a supplemental interview to capture more subtle regressions. Overall, 36.9% of children had some type of regression (27.8% language, 27.0% other-skill loss), with the supplemental interview capturing 11.7% of losses that would have been missed using the ADI-R alone. This figure is consistent with previous parent-report studies but lower than clinician-observed rates in prospective investigations. Early language losses - either full or subthreshold - and full other-skill losses appear to be associated with more deleterious outcomes by middle childhood. Findings may signify the need for more immediate and/or intense therapies for children who have even minor skill losses, particularly in language skills. Results further demonstrate the utility of an expanded set of additional queries with slightly modified criteria to capture such early, subtle losses.

Original language	English (US)
Pages (from-to)	890-898
Number of pages	9
Journal	Research in Autism Spectrum Disorders
Volume	8
Issue number	7
DOIs	https://doi.org/10.1016/j.rasd.2014.04.002
State	Published - Jul 2014

Bibliographical note

Funding Information:
This work was supported by a grant from the Simons Foundation (SFARI SSC-15 to R. Goin-Kochel and A. Beaudet). We are grateful to all of the families at the participating SFARI Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, E. Hanson, D. Grice, A. Klin, R. Kochel, D. Ledbetter, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, E. Wijsman). We appreciate obtaining access to phenotypic data on SFARI Base. Approved researchers can obtain the SSC population dataset described in this study ( http://ordering.base.sfari.org/∼browse_collection/archive[sfari_collection_v10_1]/ui:view() ) by applying at https://base.sfari.org .

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Adaptive functioning
Autism spectrum disorder
Cognition
Outcomes
Regression
Skill loss

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title = "Developmental regression among children with autism spectrum disorder: Onset, duration, and effects on functional outcomes",

abstract = "Studies using varied methods report that developmental regression occurs in a sizeable proportion of children with autism spectrum disorder (ASD). Findings are equivocal as to whether regression is associated with poorer cognitive and adaptive functioning. This study examined retrospective parent report in 2105 Simons Simplex Collection participants with ASD. Children were classified as having {"}full{"} or {"}subthreshold{"} losses on language and/or other skills using items from the Autism Diagnostic Interview-Revised (ADI-R) and a supplemental interview to capture more subtle regressions. Overall, 36.9% of children had some type of regression (27.8% language, 27.0% other-skill loss), with the supplemental interview capturing 11.7% of losses that would have been missed using the ADI-R alone. This figure is consistent with previous parent-report studies but lower than clinician-observed rates in prospective investigations. Early language losses - either full or subthreshold - and full other-skill losses appear to be associated with more deleterious outcomes by middle childhood. Findings may signify the need for more immediate and/or intense therapies for children who have even minor skill losses, particularly in language skills. Results further demonstrate the utility of an expanded set of additional queries with slightly modified criteria to capture such early, subtle losses.",

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Developmental regression among children with autism spectrum disorder: Onset, duration, and effects on functional outcomes

Abstract

Bibliographical note

Keywords

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