Resting state functional magnetic imaging (fMRI) is a novel means to examine functional brain networks. It allows investigators to identify functional networks defined by distinct, spontaneous signal fluctuations. Resting state functional connectivity (RSFC) studies examining child and adolescent psychiatric disorders are being published with increasing frequency, despite concerns about the impact of motion on findings. Here we review important RSFC findings on typical brain development and recent publications on child and adolescent psychiatric disorders. We close with a summary of the major findings and current strengths and limitations of RSFC studies.
Bibliographical noteFunding Information:
Kathryn Cullen and Leslie Hulvershorn received grants from the National Institutes of Health, the Brain and Behavior Research Foundation (formerly NARSAD). Kathryn Cullen also received funding from the Center for Translational Science Institute at the University of Minnesota, and the Academic Center at the University of Minnesota; and travel expenses covered by a National Institutes of Mental Health grant. Michael Francis received research support from the Brain and Behavior Research Foundation and Neuronetics. Melinda Westlund has no conflicts of interest.
- Brain development
- Functional MRI
- Functional connectivity
- Resting state