Developmental trajectories for young children with 16p11.2 copy number variation

Raphael Bernier, Caitlin M. Hudac, Qixuan Chen, Chubing Zeng, Arianne Stevens Wallace, Jennifer Gerdts, Rachel Earl, Jessica Peterson, Anne Wolken, Alana Peters, Ellen Hanson, Robin P. Goin-Kochel, Stephen Kanne, Lee Anne Green Snyder, Wendy K. Chung, H. Alupay, B. Aaronson, S. Ackerman, K. Ankenmann, C. AtwellE. Aylward, A. Beaudet, M. Benedetti, J. Berman, R. Bernier, A. Bibb, L. Blaskey, C. Brewton, R. Buckner, P. Bukshpun, J. Burko, B. Cerban, Q. Chen, M. Cheong, Z. Chu, W. Chung, C. Dale, A. Dempsey, J. Elgin, J. Olson, Y. Evans, W. A. Faucett, G. Fischbach, S. Garza, J. Gerdts, S. Gobuty, R. Goin-Kochel, P. E. Grant, L. Green Snyder, P. Mukherjee, on behalf of the Simons VIP consortium

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Copy number variation at 16p11.2 is associated with diverse phenotypes but little is known about the early developmental trajectories and emergence of the phenotype. This longitudinal study followed 56 children with the 16p11.2 BP4-BP5 deletion or duplication between the ages of 6 months and 8 years with diagnostic characterization and dimensional assessment across cognitive, adaptive, and behavioral domains. Linear mixed modeling revealed distinct developmental trajectories with deletions showing VIQ gains but declines in motor and social abilities while duplications showed VIQ gains and steady development across other domains. Nonparametric analyses suggest distinct trajectories and early cognitive abilities for deletion carriers who are ultimately diagnosed with intellectual disability and developmental coordination disorder as well as distinct trajectories and early social communication and cognitive abilities for duplication carriers diagnosed with ASD and intellectual disability. Findings provide predictions for patient developmental trajectories, insight into mean functioning of individuals with 16p11.2 at early ages, and highlight the need for ongoing monitoring of social and motor functioning and behavioral symptomatology to improve treatment planning.

Original languageEnglish (US)
Pages (from-to)367-380
Number of pages14
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume174
Issue number4
DOIs
StatePublished - Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Keywords

  • 16p11.2 deletion
  • 16p11.2 duplication
  • autism spectrum disorder
  • copy number variation

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