Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Darpan N. Pandya; Sylvie Pailloux; David Tatum; Darren Magda; Thaddeus J. Wadas

doi:10.1039/c4cc09256b

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Darpan N. Pandya, Sylvie Pailloux, David Tatum, Darren Magda, Thaddeus J. Wadas

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 (⁸⁹Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with ⁸⁹Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for ⁸⁹Zr.

Original language	English (US)
Pages (from-to)	2301-2303
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	12
DOIs	https://doi.org/10.1039/c4cc09256b
State	Published - Feb 11 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

Access

10.1039/c4cc09256b

OpenUrl availability

Full text

Cite this

@article{373caf4194354cbaaf3c85e757296517,

title = "Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89",

abstract = "The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 (89Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with 89Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for 89Zr.",

author = "Pandya, {Darpan N.} and Sylvie Pailloux and David Tatum and Darren Magda and Wadas, {Thaddeus J.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = feb,

day = "11",

doi = "10.1039/c4cc09256b",

language = "English (US)",

volume = "51",

pages = "2301--2303",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "12",

}

TY - JOUR

T1 - Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

AU - Pandya, Darpan N.

AU - Pailloux, Sylvie

AU - Tatum, David

AU - Magda, Darren

AU - Wadas, Thaddeus J.

PY - 2015/2/11

Y1 - 2015/2/11

N2 - The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 (89Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with 89Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for 89Zr.

AB - The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 (89Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with 89Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for 89Zr.

UR - http://www.scopus.com/inward/record.url?scp=84921843699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921843699&partnerID=8YFLogxK

U2 - 10.1039/c4cc09256b

DO - 10.1039/c4cc09256b

M3 - Article

C2 - 25556851

AN - SCOPUS:84921843699

SN - 1359-7345

VL - 51

SP - 2301

EP - 2303

JO - Chemical Communications

JF - Chemical Communications

IS - 12

ER -

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this