Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89

Darpan N. Pandya, Sylvie Pailloux, David Tatum, Darren Magda, Thaddeus J. Wadas

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 (89Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with 89Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for 89Zr.

Original languageEnglish (US)
Pages (from-to)2301-2303
Number of pages3
JournalChemical Communications
Volume51
Issue number12
DOIs
StatePublished - Feb 11 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

Fingerprint

Dive into the research topics of 'Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89'. Together they form a unique fingerprint.

Cite this