TY - JOUR
T1 - Diagnosis and assessment of treatment effects
T2 - A single 24-hour blood pressure monitoring profile
AU - Siegelova, J.
AU - Cornelissen, G.
AU - Dusek, J.
AU - Fiser, B.
AU - Watanabe, Y.
AU - Otsuka, K.
AU - Halberg, F.
PY - 1998
Y1 - 1998
N2 - The hypotensive effect of verapamil, enalapril and nitrendipine was tested on 29 patients. The blood pressure and heart rate of each patient was measured around the clock for 24 hours with an ambulatory monitor on two occasions, on placebo, and on treatment. Results indicate that: 1. not all patients are diagnosed with MESOR-hypertension while on placebo; 2. a statistically significant decrease in blood pressure on treatment cannot invariably be demonstrated on an individualized basis; and 3. on a group basis, differential drug effects on the circadian amplitude of blood pressure are documented. For an individual assessment of a patient's response to antihypertensive treatment, monitoring over spans longer than 24 hours is advocated, preferably for 7 days at the outset.
AB - The hypotensive effect of verapamil, enalapril and nitrendipine was tested on 29 patients. The blood pressure and heart rate of each patient was measured around the clock for 24 hours with an ambulatory monitor on two occasions, on placebo, and on treatment. Results indicate that: 1. not all patients are diagnosed with MESOR-hypertension while on placebo; 2. a statistically significant decrease in blood pressure on treatment cannot invariably be demonstrated on an individualized basis; and 3. on a group basis, differential drug effects on the circadian amplitude of blood pressure are documented. For an individual assessment of a patient's response to antihypertensive treatment, monitoring over spans longer than 24 hours is advocated, preferably for 7 days at the outset.
KW - 24-h blood pressure
KW - Essential hypertension
KW - Treatment effect
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M3 - Article
AN - SCOPUS:0032408775
SN - 1211-3395
VL - 71
SP - 209
EP - 213
JO - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
JF - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
IS - 4
ER -