Abstract
The study of the N-quaternization of substituted piperidines has been mostly dormant for the last 40 years, despite the demand for ammonium salts as drugs, ionic liquids, chiral catalysts or ligands, phase transfer reagents, and reagents for the Stevens and Sommelet-Hauser rearrangements. In this perspective article, the complexity of this seemingly simple reaction is studied by a summary and analysis of literature experimental results. Computational methods are applied to various literature reactions as case studies.
Original language | English (US) |
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Pages (from-to) | 468-476 |
Number of pages | 9 |
Journal | Canadian Journal of Chemistry |
Volume | 93 |
Issue number | 4 |
DOIs | |
State | Published - 2015 |
Bibliographical note
Publisher Copyright:© 2015 Published by NRC Research Press.
Keywords
- Diastereoselective N-quaternization
- N-alkylation of piperidines
- Piperidinium salts