Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells

James R. Lokensgard, Genya Gekker, Shuxian Hu, Andrew F. Arthur, Chun C. Chao, Phillip K. Peterson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.

Original languageEnglish (US)
Pages (from-to)2566-2569
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume41
Issue number11
DOIs
StatePublished - Nov 1997

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