Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Claudio Pelucchi, V. Rosato, P. M. Bracci, D. Li, R. E. Neale, E. Lucenteforte, D. Serraino, K. E. Anderson, E. Fontham, E. A. Holly, M. M. Hassan, J. Polesel, C. Bosetti, L. Strayer, J. Su, P. Boffetta, E. J. Duell, C. La Vecchia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Occupational exposure to acrylamide was associated with excess mortality from pancreatic cancer, though in the absence of dose-risk relationship. Few epidemiological studies have examined the association between acrylamide from diet and pancreatic cancer risk. Patients and methods: We considered this issue in a combined set of 1975 cases of pancreatic cancer and 4239 controls enrolled in six studies of the Pancreatic Cancer Case-Control Consortium (PanC4). We calculated pooled odds ratios (ORs) and their 95% confidence intervals (CI) by estimating study-specific ORs through multivariate unconditional logistic regression models and pooling the obtained estimates using random-effects models. Results: Compared with the lowest level of estimated dietary acrylamide intake, the pooled ORs were 0.97 (95% CI, 0.79-1.19) for the second, 0.91 (95% CI, 0.71-1.16) for the third, and 0.92 (95% CI, 0.66-1.28) for the fourth (highest) quartile of intake. For an increase of 10 mg/day of acrylamide intake, the pooled OR was 0.96 (95% CI, 0.87-1.06), with heterogeneity between estimates (I2 = 67%). Results were similar across various subgroups, and were confirmed when using a one-stage modelling approach. Conclusions: This PanC4 pooled-analysis found no association between dietary acrylamide and pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalAnnals of Oncology
Issue number2
StatePublished - Feb 2017

Bibliographical note

Funding Information:
The project was conducted thanks to funding from the Italian Ministry of Health, General Directorate of European and International Relations, and the Italian Foundation for Research on Cancer (FIRC). V.R. was supported by a fellowship from the Italian Foundation for Research on Cancer (FIRC #18107). R.E.N. is funded by a fellowship from the National Health and Medical Research Council (NHMRC, Australia). The Queensland Pancreatic Cancer Study was funded by a project grant from theNHMRC.

Publisher Copyright:
© The Author 2016.


  • Acrylamide
  • Case-control studies
  • Pancreatic neoplasms
  • Pooled-analysis
  • Risk factors

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