Dietary fat intake and carotid artery wall thickness: The atherosclerosis risk in communities (ARIC) study

Grethe S. Tell; Gregory W. Evans; Aaron R. Folsom; Tomoko Shimakawa; Myra A. Carpenter; Gerardo Heiss

doi:10.1093/oxfordjournals.aje.a116947

Dietary fat intake and carotid artery wall thickness: The atherosclerosis risk in communities (ARIC) study

Grethe S. Tell, Gregory W. Evans, Aaron R. Folsom, Tomoko Shimakawa, Myra A. Carpenter, Gerardo Heiss

Epidemiology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Associations between atherosclerosis and dietary fat and cholesterol have been demonstrated in numerous animal experiments. The relation between these dietary components and atherosclerosis has not previously been reported in a population-based study among human beings. The associations of dietary fat and cholesterol with carotid artery wall thickness (atherosclerosis) were investigated in a population-based study, the Atherosclerosis Risk in Communities (ARIC) Study, from 1987 to 1989. Participants were 2,095 black women, 5,146 white women, 1,318 black men and 4,589 white men, aged 45-64 years, recruited from four US communities: Jackson, Mississippi; Forsyth County, North Carolina; Washington County, Maryland; and Minneapolis, Minnesota. Habitual diet was assessed with a food frequency questionnaire. Wall thickness was measured with B-mode ultrasound. After adjustment for age and energy intake, animal fat, saturated fat, monounsaturated fat, cholesterol, and Keys' score were positively related to wall thickness, while vegetable fat and polyunsaturated fat were inversely related to wall thickness. These associations persisted after further adjustment for smoking and hypertension and were consistent across the four race and sex groups. Thus, elements of habitual dietary intake were consistently associated with carotid artery wall thickness, compatible with their putatively atherogenic and antiatherogenic properties.

Original language	English (US)
Pages (from-to)	979-989
Number of pages	11
Journal	American journal of epidemiology
Volume	139
Issue number	10
DOIs	https://doi.org/10.1093/oxfordjournals.aje.a116947
State	Published - May 15 1994

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities (ARIC) Study is carried out as a collaborative study supported by contracts NO1-HC-55015, NO1-HC-55016, NO1-HC-55018, NO1-HC-55019, HC-55020, NO1-HC-55021, and NO1-HC-55022 from the National Heart, Lung, and Blood Institute. The authors thank the following interviewers and sonographers for their invaluable help with the ARIC Study data collection: Forsyth County, NC—Betty Barnhardt, Jean Marlow, Cathy Tatum, and Wilma Slyman (interviewers), Amy Haire, Bonnie Monger, and Cathy Rachui (sonographers); Jackson, MS—Bobbie Alliston, Brenda Askew, and Brenda Watson (interviewers), Faye Blackburn, Lisa Fields, and Shirley Willis (sonographers); Minneapolis, MN— Marilyn Bowers, Dorothy Buckingham, and Barbara Kuehl (interviewers), Irene Keske, Bryna Lester, Gail Murton, and Margaret Skelton (sonographers); Washington County, MD: Carol Christman, Sunny Harrell, Joel Hill, Trudy Littenberg, and Joan Nelling (interviewers), Dorrie Costa and Beverly Kittle (sonographers). The authors also thank Dr. Walter Willett and Laura Sampson for permission and assistance in using and scoring the Harvard Food Frequency Questionnaire.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Arteries
Atherosclerosis
Cholesterol
Dietary fats
Ultrasonography

Access

10.1093/oxfordjournals.aje.a116947

OpenUrl availability

Full text

Cite this

@article{c24f3696ca3246e1aac86d581095db62,

title = "Dietary fat intake and carotid artery wall thickness: The atherosclerosis risk in communities (ARIC) study",

abstract = "Associations between atherosclerosis and dietary fat and cholesterol have been demonstrated in numerous animal experiments. The relation between these dietary components and atherosclerosis has not previously been reported in a population-based study among human beings. The associations of dietary fat and cholesterol with carotid artery wall thickness (atherosclerosis) were investigated in a population-based study, the Atherosclerosis Risk in Communities (ARIC) Study, from 1987 to 1989. Participants were 2,095 black women, 5,146 white women, 1,318 black men and 4,589 white men, aged 45-64 years, recruited from four US communities: Jackson, Mississippi; Forsyth County, North Carolina; Washington County, Maryland; and Minneapolis, Minnesota. Habitual diet was assessed with a food frequency questionnaire. Wall thickness was measured with B-mode ultrasound. After adjustment for age and energy intake, animal fat, saturated fat, monounsaturated fat, cholesterol, and Keys' score were positively related to wall thickness, while vegetable fat and polyunsaturated fat were inversely related to wall thickness. These associations persisted after further adjustment for smoking and hypertension and were consistent across the four race and sex groups. Thus, elements of habitual dietary intake were consistently associated with carotid artery wall thickness, compatible with their putatively atherogenic and antiatherogenic properties.",

keywords = "Arteries, Atherosclerosis, Cholesterol, Dietary fats, Ultrasonography",

author = "Tell, {Grethe S.} and Evans, {Gregory W.} and Folsom, {Aaron R.} and Tomoko Shimakawa and Carpenter, {Myra A.} and Gerardo Heiss",

note = "Funding Information: The Atherosclerosis Risk in Communities (ARIC) Study is carried out as a collaborative study supported by contracts NO1-HC-55015, NO1-HC-55016, NO1-HC-55018, NO1-HC-55019, HC-55020, NO1-HC-55021, and NO1-HC-55022 from the National Heart, Lung, and Blood Institute. The authors thank the following interviewers and sonographers for their invaluable help with the ARIC Study data collection: Forsyth County, NC—Betty Barnhardt, Jean Marlow, Cathy Tatum, and Wilma Slyman (interviewers), Amy Haire, Bonnie Monger, and Cathy Rachui (sonographers); Jackson, MS—Bobbie Alliston, Brenda Askew, and Brenda Watson (interviewers), Faye Blackburn, Lisa Fields, and Shirley Willis (sonographers); Minneapolis, MN— Marilyn Bowers, Dorothy Buckingham, and Barbara Kuehl (interviewers), Irene Keske, Bryna Lester, Gail Murton, and Margaret Skelton (sonographers); Washington County, MD: Carol Christman, Sunny Harrell, Joel Hill, Trudy Littenberg, and Joan Nelling (interviewers), Dorrie Costa and Beverly Kittle (sonographers). The authors also thank Dr. Walter Willett and Laura Sampson for permission and assistance in using and scoring the Harvard Food Frequency Questionnaire. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1994",

month = may,

day = "15",

doi = "10.1093/oxfordjournals.aje.a116947",

language = "English (US)",

volume = "139",

pages = "979--989",

journal = "American journal of epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Dietary fat intake and carotid artery wall thickness

T2 - The atherosclerosis risk in communities (ARIC) study

AU - Tell, Grethe S.

AU - Evans, Gregory W.

AU - Folsom, Aaron R.

AU - Shimakawa, Tomoko

AU - Carpenter, Myra A.

AU - Heiss, Gerardo

N1 - Funding Information: The Atherosclerosis Risk in Communities (ARIC) Study is carried out as a collaborative study supported by contracts NO1-HC-55015, NO1-HC-55016, NO1-HC-55018, NO1-HC-55019, HC-55020, NO1-HC-55021, and NO1-HC-55022 from the National Heart, Lung, and Blood Institute. The authors thank the following interviewers and sonographers for their invaluable help with the ARIC Study data collection: Forsyth County, NC—Betty Barnhardt, Jean Marlow, Cathy Tatum, and Wilma Slyman (interviewers), Amy Haire, Bonnie Monger, and Cathy Rachui (sonographers); Jackson, MS—Bobbie Alliston, Brenda Askew, and Brenda Watson (interviewers), Faye Blackburn, Lisa Fields, and Shirley Willis (sonographers); Minneapolis, MN— Marilyn Bowers, Dorothy Buckingham, and Barbara Kuehl (interviewers), Irene Keske, Bryna Lester, Gail Murton, and Margaret Skelton (sonographers); Washington County, MD: Carol Christman, Sunny Harrell, Joel Hill, Trudy Littenberg, and Joan Nelling (interviewers), Dorrie Costa and Beverly Kittle (sonographers). The authors also thank Dr. Walter Willett and Laura Sampson for permission and assistance in using and scoring the Harvard Food Frequency Questionnaire. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1994/5/15

Y1 - 1994/5/15

N2 - Associations between atherosclerosis and dietary fat and cholesterol have been demonstrated in numerous animal experiments. The relation between these dietary components and atherosclerosis has not previously been reported in a population-based study among human beings. The associations of dietary fat and cholesterol with carotid artery wall thickness (atherosclerosis) were investigated in a population-based study, the Atherosclerosis Risk in Communities (ARIC) Study, from 1987 to 1989. Participants were 2,095 black women, 5,146 white women, 1,318 black men and 4,589 white men, aged 45-64 years, recruited from four US communities: Jackson, Mississippi; Forsyth County, North Carolina; Washington County, Maryland; and Minneapolis, Minnesota. Habitual diet was assessed with a food frequency questionnaire. Wall thickness was measured with B-mode ultrasound. After adjustment for age and energy intake, animal fat, saturated fat, monounsaturated fat, cholesterol, and Keys' score were positively related to wall thickness, while vegetable fat and polyunsaturated fat were inversely related to wall thickness. These associations persisted after further adjustment for smoking and hypertension and were consistent across the four race and sex groups. Thus, elements of habitual dietary intake were consistently associated with carotid artery wall thickness, compatible with their putatively atherogenic and antiatherogenic properties.

AB - Associations between atherosclerosis and dietary fat and cholesterol have been demonstrated in numerous animal experiments. The relation between these dietary components and atherosclerosis has not previously been reported in a population-based study among human beings. The associations of dietary fat and cholesterol with carotid artery wall thickness (atherosclerosis) were investigated in a population-based study, the Atherosclerosis Risk in Communities (ARIC) Study, from 1987 to 1989. Participants were 2,095 black women, 5,146 white women, 1,318 black men and 4,589 white men, aged 45-64 years, recruited from four US communities: Jackson, Mississippi; Forsyth County, North Carolina; Washington County, Maryland; and Minneapolis, Minnesota. Habitual diet was assessed with a food frequency questionnaire. Wall thickness was measured with B-mode ultrasound. After adjustment for age and energy intake, animal fat, saturated fat, monounsaturated fat, cholesterol, and Keys' score were positively related to wall thickness, while vegetable fat and polyunsaturated fat were inversely related to wall thickness. These associations persisted after further adjustment for smoking and hypertension and were consistent across the four race and sex groups. Thus, elements of habitual dietary intake were consistently associated with carotid artery wall thickness, compatible with their putatively atherogenic and antiatherogenic properties.

KW - Arteries

KW - Atherosclerosis

KW - Cholesterol

KW - Dietary fats

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=0028237087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028237087&partnerID=8YFLogxK

U2 - 10.1093/oxfordjournals.aje.a116947

DO - 10.1093/oxfordjournals.aje.a116947

M3 - Article

C2 - 8178786

AN - SCOPUS:0028237087

SN - 0002-9262

VL - 139

SP - 979

EP - 989

JO - American journal of epidemiology

JF - American journal of epidemiology

IS - 10

ER -

Dietary fat intake and carotid artery wall thickness: The atherosclerosis risk in communities (ARIC) study

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this