Cholestoral oxidation products (COPS) are clearly cytotoxic to a wide variety of cells in culture. Other lipid oxidation products (LOPS), notably aldehyde products of fatty acid oxidation, are also cytotoxic. Are LOPS, including COPS, also atherogenic? Recent research has clearly demonstrated the postprandial absorption of COPS in humans. Only 10 to 20% of postprandial plasma COPS were associated with isolated chylomicron fraction, suggesting that dietary COPS were associated with isolated chylomicron fraction, suggesting that dietary COPS may be transferred rapidly to other lipoprotein fractions, including low density lipoprotein (LDL). Indeed, LDL isolated from fasting subjects contains detectable levels of COPS. Meanwhile, mounting evidence continues to implicate the oxidative modification of native (nonatherogenic) LDL as an obligatory step in numerous atherogenic processes. Therefore, the hypothesis that COPS in LDL render LDL more susceptibility to oxidative modification was studied. Results indicate that the susceptibility of LDL to oxidative modification (as Measured by conjugated diene formation) was not altered when up to 2% of the total cholesterol in LDL, it remains quite possible that lipoprotein-mediated delivery of COPS to cells at the site of atherogenesis may be deleterious. LDL-mediated delivery of COPS to HepG2 cells in culture was demonstrated, raising the possibility that dietary COPS could alter cholesterol metabolism in the liver.
|Original language||English (US)|
|Journal||Canadian Journal of Cardiology|
|Issue number||SUPPL. B|
|State||Published - Jan 1 1993|