Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

Jianmin Wu; Ying Zhao; Xian Wang; Lingchang Kong; Lee J. Johnston; Lin Lu; Xi Ma

doi:10.1080/10408398.2020.1828813

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

Jianmin Wu, Ying Zhao, Xian Wang, Lingchang Kong, Lee J. Johnston, Lin Lu, Xi Ma

West Central Research and Outreach Center

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and function, then further damages the functions and homeostasis of distal organs, leading to systemic diseases. Nutrients, transplantation of bacteria flora and modes of life can shape gut microbiota and intestinal mucosa barrier and mitigate stress. Current researches demonstrate that dynamic epigenetic modifications of intestinal tissue strongly mediate the crosstalk between gut microbes and gut mucosa barrier. Lactobacillus and Bifidobacterium species can synthesize folate to increase DNA methylation and mRNA N6-methyladenosine (m6A) of gut, which ensures intestinal normal development. Clostridial cluster, Anaerostipes and Eubacterium can induce histone acylation modifications by butyrate to enhance the development and immune balance of gut. Herein, we summarizes the present scientific understanding of how dietary nutrients shape gut microbiota and further regulate intestinal mucosa functions via epigenetic modifications, which will shed light on manipulation of gut microbiota by dietary nutrients, for prevention or clinical treatment of intestinal diseases.

Original language	English (US)
Pages (from-to)	783-797
Number of pages	15
Journal	Critical Reviews in Food Science and Nutrition
Volume	62
Issue number	3
DOIs	https://doi.org/10.1080/10408398.2020.1828813
State	Published - 2022

Bibliographical note

Funding Information:
This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31930106, 31829004 and 31722054), the National Ten-thousand Talents Program of China (23070201), the Key Research & Developmental Program of Shandong Province (2019JZZY020308), and the 111 Project (B16044). Our profound admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations.

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

Dietary nutrients
acetylation
crotonylation
epigenetic modification
gut microbiota
intestinal mucosa
methylation

PubMed: MeSH publication types

Journal Article

Access

10.1080/10408398.2020.1828813

OpenUrl availability

Full text

Cite this

@article{cb5e34acbeeb47e8bddb7a55d13c55ab,

title = "Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications",

abstract = "The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and function, then further damages the functions and homeostasis of distal organs, leading to systemic diseases. Nutrients, transplantation of bacteria flora and modes of life can shape gut microbiota and intestinal mucosa barrier and mitigate stress. Current researches demonstrate that dynamic epigenetic modifications of intestinal tissue strongly mediate the crosstalk between gut microbes and gut mucosa barrier. Lactobacillus and Bifidobacterium species can synthesize folate to increase DNA methylation and mRNA N6-methyladenosine (m6A) of gut, which ensures intestinal normal development. Clostridial cluster, Anaerostipes and Eubacterium can induce histone acylation modifications by butyrate to enhance the development and immune balance of gut. Herein, we summarizes the present scientific understanding of how dietary nutrients shape gut microbiota and further regulate intestinal mucosa functions via epigenetic modifications, which will shed light on manipulation of gut microbiota by dietary nutrients, for prevention or clinical treatment of intestinal diseases.",

keywords = "Dietary nutrients, acetylation, crotonylation, epigenetic modification, gut microbiota, intestinal mucosa, methylation",

author = "Jianmin Wu and Ying Zhao and Xian Wang and Lingchang Kong and Johnston, {Lee J.} and Lin Lu and Xi Ma",

note = "Funding Information: This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31930106, 31829004 and 31722054), the National Ten-thousand Talents Program of China (23070201), the Key Research & Developmental Program of Shandong Province (2019JZZY020308), and the 111 Project (B16044). Our profound admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2022",

doi = "10.1080/10408398.2020.1828813",

language = "English (US)",

volume = "62",

pages = "783--797",

journal = "Critical Reviews in Food Science and Nutrition",

issn = "1040-8398",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

AU - Wu, Jianmin

AU - Zhao, Ying

AU - Wang, Xian

AU - Kong, Lingchang

AU - Johnston, Lee J.

AU - Lu, Lin

AU - Ma, Xi

N1 - Funding Information: This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31930106, 31829004 and 31722054), the National Ten-thousand Talents Program of China (23070201), the Key Research & Developmental Program of Shandong Province (2019JZZY020308), and the 111 Project (B16044). Our profound admiration and respect go to researchers in this field and in our laboratories for their dedication and hard work. We apologize to scientists whose work is in this field but their papers are not cited in this review owing to space limitations. Publisher Copyright: © 2020 Taylor & Francis Group, LLC.

PY - 2022

Y1 - 2022

N2 - The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and function, then further damages the functions and homeostasis of distal organs, leading to systemic diseases. Nutrients, transplantation of bacteria flora and modes of life can shape gut microbiota and intestinal mucosa barrier and mitigate stress. Current researches demonstrate that dynamic epigenetic modifications of intestinal tissue strongly mediate the crosstalk between gut microbes and gut mucosa barrier. Lactobacillus and Bifidobacterium species can synthesize folate to increase DNA methylation and mRNA N6-methyladenosine (m6A) of gut, which ensures intestinal normal development. Clostridial cluster, Anaerostipes and Eubacterium can induce histone acylation modifications by butyrate to enhance the development and immune balance of gut. Herein, we summarizes the present scientific understanding of how dietary nutrients shape gut microbiota and further regulate intestinal mucosa functions via epigenetic modifications, which will shed light on manipulation of gut microbiota by dietary nutrients, for prevention or clinical treatment of intestinal diseases.

AB - The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and function, then further damages the functions and homeostasis of distal organs, leading to systemic diseases. Nutrients, transplantation of bacteria flora and modes of life can shape gut microbiota and intestinal mucosa barrier and mitigate stress. Current researches demonstrate that dynamic epigenetic modifications of intestinal tissue strongly mediate the crosstalk between gut microbes and gut mucosa barrier. Lactobacillus and Bifidobacterium species can synthesize folate to increase DNA methylation and mRNA N6-methyladenosine (m6A) of gut, which ensures intestinal normal development. Clostridial cluster, Anaerostipes and Eubacterium can induce histone acylation modifications by butyrate to enhance the development and immune balance of gut. Herein, we summarizes the present scientific understanding of how dietary nutrients shape gut microbiota and further regulate intestinal mucosa functions via epigenetic modifications, which will shed light on manipulation of gut microbiota by dietary nutrients, for prevention or clinical treatment of intestinal diseases.

KW - Dietary nutrients

KW - acetylation

KW - crotonylation

KW - epigenetic modification

KW - gut microbiota

KW - intestinal mucosa

KW - methylation

UR - http://www.scopus.com/inward/record.url?scp=85092493240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85092493240&partnerID=8YFLogxK

U2 - 10.1080/10408398.2020.1828813

DO - 10.1080/10408398.2020.1828813

M3 - Review article

C2 - 33043708

AN - SCOPUS:85092493240

SN - 1040-8398

VL - 62

SP - 783

EP - 797

JO - Critical Reviews in Food Science and Nutrition

JF - Critical Reviews in Food Science and Nutrition

IS - 3

ER -

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this