Dietary Protein Sources and Risk for Incident Chronic Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study

Bernhard Haring, Elizabeth Selvin, Menglu Liang, Josef Coresh, Morgan E. Grams, Natalia Petruski-Ivleva, Lyn M. Steffen, Casey M. Rebholz

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Objective Dietary protein restriction is recommended for patients with moderate to severe renal insufficiency. Long-term data on the relationship between dietary protein sources and risk for incident kidney disease in individuals with normal kidney function are largely missing. This study aimed to assess the association between dietary protein sources and incident chronic kidney disease (CKD). Design Prospective cohort. Setting Atherosclerosis Risk in Communities study participants from 4 US communities. Subjects A total of 11,952 adults aged 44-66 years in 1987-1989 who were free of diabetes mellitus, cardiovascular disease, and had an estimated glomerular filtration rate (eGFR) ≥ 60 mL/minute/1.73 m2. Main Outcome Measure A 66-item food frequency questionnaire was used to assess food intake. CKD stage 3 was defined as a decrease in eGFR of ≥25% from baseline resulting in an eGFR of less than 60 mL/minute/1.73 m2; CKD-related hospitalization; CKD-related death; or end-stage renal disease. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression. Results During a median follow-up of 23 years, there were 2,632 incident CKD cases. Red and processed meat consumption was associated with increased CKD risk (HRQ5 vs. Q1: 1.23, 95% CI: 1.06-1.42, ptrend = 0.01). In contrast, higher dietary intake of nuts, legumes, and low-fat dairy products was associated with lower CKD risk (nuts: HRQ5 vs. Q1: 0.81, 95% CI: 0.72-0.92, ptrend <0.001; low-fat dairy products: HRQ5 vs. Q1: 0.75, 95% CI: 0.65-0.85, ptrend <0.001; legumes: HRQ5 vs. Q1: 0.83, 95% CI: 0.72-0.95, ptrend = 0.03). Conclusion There were varied associations of specific dietary protein sources with risk of incident CKD; with red and processed meat being adversely associated with CKD risk; and nuts, low-fat dairy products, and legumes being protective against the development of CKD.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalJournal of Renal Nutrition
Volume27
Issue number4
DOIs
StatePublished - Jul 2017

Bibliographical note

Funding Information:
Support: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). There are no relationships with industry to declare. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. E.S. was supported by NIH/NIDDK grant K24DK106414. C.M.R. was supported by NIH/NIDDK grant K01 DK107782.

Publisher Copyright:
© 2016 National Kidney Foundation, Inc.

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