Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T

Hermien E. Kan, Aranee Techawiboonwong, Matthias J.P. Van Osch, Maarten J. Versluis, Dinesh K. Deelchand, Pierre Gilles Henry, Małgorzata Marjańska, Mark A. Van Buchem, Andrew G. Webb, Itamar Ronen

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Diffusion weighted spectroscopy can provide microstructural information that is specific to compartmental geometry. So far, in human brain, apparent diffusion coefficients (ADCs) of only the metabolites N-acetyl aspartate, creatine (tCr) and choline (tCho) have been assessed. High field MR at 7 T allows the collection and analysis of diffusion weighted spectroscopy data of additional metabolites of interest such as glutamate (Glu), N-acetyl aspartyl glutamate, and glutamine (Gln), which are of interest due to their different compartmentalization and role in brain physiology. In this study, we performed 1H diffusion weighted spectroscopy at 7 T using a diffusion-weighted PRESS sequence in parietal white matter (n = 6) and occipital grey matter (n = 7). Data were analyzed using the LCmodel. ADCs could reliably be obtained of N-acetyl aspartate, tCr, tCho, Glu, Gln in grey and white matter, and N-acetyl aspartyl glutamate in white matter. Significant differences in ADC values were observed between grey and white matter for all metabolites. ADCs in grey matter were consistently lower than in white matter. These differences can probably be attributed to different compartmentalization as well as to the differential impact of diffusion time on ADC of different molecules under conditions of restricted diffusion.

Original languageEnglish (US)
Pages (from-to)1203-1209
Number of pages7
JournalMagnetic resonance in medicine
Volume67
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • DWS
  • MRS
  • N-acetyl aspartyl glutamate
  • PRESS
  • diffusion
  • glutamate

Fingerprint Dive into the research topics of 'Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T'. Together they form a unique fingerprint.

Cite this