Differences in transmission through the dorsal column nuclei in spontaneously hypertensive and Wistar Kyoto rats

James T. Garsik; Walter C. Low; David Whitehorn

doi:10.1016/0006-8993(83)91384-7

Differences in transmission through the dorsal column nuclei in spontaneously hypertensive and Wistar Kyoto rats

James T. Garsik, Walter C. Low, David Whitehorn

Neurosurgery

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Abstract

The medial lemniscal evoked potential in response to a range of footshock intensities was recorded in spontaneously hypertensive (SHR) and Wistar Kyoto rats (WKY). Input-output (I-O) relationships were constructed as the percent of maximum response at each intensity. The SHR had a steeper I-O relationship than did the WKY. This difference was also evident when SHR maintained normotensive from weaning with hydralazine were compared with identically treated WKY. The treatment itself steepened the I-O relationship of the SHR while leaving that of the WKY unchanged. These results indicate an inherent hyperresponsiveness in the SHR dorsal column nuclei and an inhibitory effect of elevated blood pressure on transmission through these nuclei.

Original language	English (US)
Pages (from-to)	188-192
Number of pages	5
Journal	Brain Research
Volume	271
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)91384-7
State	Published - Jul 18 1983

Bibliographical note

Funding Information:
Supported by HL24110 (D.W.), Vermont Heart Association Grant in Aid (D.W.) and HL06339 (W.C.L.).

Keywords

medial lemniscus
sensory modulation
spontaneously hypertensive rat

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title = "Differences in transmission through the dorsal column nuclei in spontaneously hypertensive and Wistar Kyoto rats",

abstract = "The medial lemniscal evoked potential in response to a range of footshock intensities was recorded in spontaneously hypertensive (SHR) and Wistar Kyoto rats (WKY). Input-output (I-O) relationships were constructed as the percent of maximum response at each intensity. The SHR had a steeper I-O relationship than did the WKY. This difference was also evident when SHR maintained normotensive from weaning with hydralazine were compared with identically treated WKY. The treatment itself steepened the I-O relationship of the SHR while leaving that of the WKY unchanged. These results indicate an inherent hyperresponsiveness in the SHR dorsal column nuclei and an inhibitory effect of elevated blood pressure on transmission through these nuclei.",

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AU - Low, Walter C.

AU - Whitehorn, David

N1 - Funding Information: Supported by HL24110 (D.W.), Vermont Heart Association Grant in Aid (D.W.) and HL06339 (W.C.L.).

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N2 - The medial lemniscal evoked potential in response to a range of footshock intensities was recorded in spontaneously hypertensive (SHR) and Wistar Kyoto rats (WKY). Input-output (I-O) relationships were constructed as the percent of maximum response at each intensity. The SHR had a steeper I-O relationship than did the WKY. This difference was also evident when SHR maintained normotensive from weaning with hydralazine were compared with identically treated WKY. The treatment itself steepened the I-O relationship of the SHR while leaving that of the WKY unchanged. These results indicate an inherent hyperresponsiveness in the SHR dorsal column nuclei and an inhibitory effect of elevated blood pressure on transmission through these nuclei.

AB - The medial lemniscal evoked potential in response to a range of footshock intensities was recorded in spontaneously hypertensive (SHR) and Wistar Kyoto rats (WKY). Input-output (I-O) relationships were constructed as the percent of maximum response at each intensity. The SHR had a steeper I-O relationship than did the WKY. This difference was also evident when SHR maintained normotensive from weaning with hydralazine were compared with identically treated WKY. The treatment itself steepened the I-O relationship of the SHR while leaving that of the WKY unchanged. These results indicate an inherent hyperresponsiveness in the SHR dorsal column nuclei and an inhibitory effect of elevated blood pressure on transmission through these nuclei.

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KW - sensory modulation

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Differences in transmission through the dorsal column nuclei in spontaneously hypertensive and Wistar Kyoto rats

Abstract

Bibliographical note

Keywords

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