Differential effect of aspirin versus warfarin on clinical stroke types in patients with atrial fibrillation

V. T. Miller, L. A. Pearce, W. M. Feinberg, J. F. Rothrock, D. C. Anderson, R. G. Hart

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The Stroke Prevention in Atrial Fibrillation II study compared the efficacy and safety of aspirin and warfarin in patients with atrial fibrillation. Three neurologists, blinded to patient therapy, categorized the pathophysiology of ischemic strokes that occurred in the trial based on predetermined clinical criteria. Upon analyzing the patients being treated with these two drugs, warfarin proved significantly more effective than aspirin in preventing cardioembolic strokes (p = 0.005) and strokes of uncertain pathophysiology (p = 0.01). There was no significant difference in the efficacy for prevention of noncardioembolic strokes.

Original languageEnglish (US)
Pages (from-to)238-240
Number of pages3
JournalNeurology
Volume46
Issue number1
DOIs
StatePublished - Jan 1996

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