TY - JOUR
T1 - Differential effects of morphine, DPDPE, and U-50488 on apomorphine-induced climbing behavior in μ-opioid receptor knockout mice
AU - Jang, Choon Gon
AU - Lee, Seok Yong
AU - Park, Younjoo
AU - Ma, Tangeng
AU - Loh, Horace H.
AU - Ho, Ing K.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/10/19
Y1 - 2001/10/19
N2 - The present study examined the hypothesis whether the opioid receptors (μ, δ, and κ) contribute to a behavioral dopaminergic activation produced by dopamine receptor agonist, apomorphine, by comparing responses in wild type and μ-opioid receptor knockout mice. The data suggest that expression of μ-opioid receptors plays an important role in the enhancement of climbing behavior induced by apomorphine. Compared to wild type mice, a response in the dopaminergic behavior by treatment with δ-receptor agonist, DPDPE, is more sensitive to the mice lacking μ-opioid receptor. Treatment with κ-receptor agonist, U-50488, is potentiated the apomorphine-induced climbing behavior in wild type and μ-opioid receptor knockout mice. These responses may be independent of that through μ-opioid receptors. Therefore, the our results show that dopaminergic activation measured by climbing behavior in μ-opioid receptors knockout mice are differently regulated by μ-, δ-, and κ-opioid receptor agonists.
AB - The present study examined the hypothesis whether the opioid receptors (μ, δ, and κ) contribute to a behavioral dopaminergic activation produced by dopamine receptor agonist, apomorphine, by comparing responses in wild type and μ-opioid receptor knockout mice. The data suggest that expression of μ-opioid receptors plays an important role in the enhancement of climbing behavior induced by apomorphine. Compared to wild type mice, a response in the dopaminergic behavior by treatment with δ-receptor agonist, DPDPE, is more sensitive to the mice lacking μ-opioid receptor. Treatment with κ-receptor agonist, U-50488, is potentiated the apomorphine-induced climbing behavior in wild type and μ-opioid receptor knockout mice. These responses may be independent of that through μ-opioid receptors. Therefore, the our results show that dopaminergic activation measured by climbing behavior in μ-opioid receptors knockout mice are differently regulated by μ-, δ-, and κ-opioid receptor agonists.
KW - Climbing behavior
KW - DPDPE
KW - Morphine
KW - U-50488
KW - μ-Opioid receptor knockout mice
UR - http://www.scopus.com/inward/record.url?scp=0035914177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035914177&partnerID=8YFLogxK
U2 - 10.1016/S0169-328X(01)00227-3
DO - 10.1016/S0169-328X(01)00227-3
M3 - Article
C2 - 11597780
AN - SCOPUS:0035914177
SN - 0169-328X
VL - 94
SP - 197
EP - 199
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -