Abstract
Today, –omics analyses, including the systematic cataloging of messenger RNA and microRNA sequences or DNA methylation patterns in a cell population, organ, or tissue sample, allow for an unbiased, comprehensive genome-level analysis of complex diseases, offering a large advantage over earlier “candidate” gene or pathway analyses. A primary goal in the analysis of these high-throughput assays is the detection of those features among several thousand that differ between different groups of samples. In the context of oral biology, our group has successfully utilized –omics technology to identify key molecules and pathways in different diagnostic entities of periodontal disease.
Original language | English (US) |
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Title of host publication | Methods in Molecular Biology |
Publisher | Humana Press Inc. |
Pages | 327-345 |
Number of pages | 19 |
DOIs | |
State | Published - 2017 |
Publication series
Name | Methods in Molecular Biology |
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Volume | 1537 |
ISSN (Print) | 1064-3745 |
Bibliographical note
Publisher Copyright:© Springer Science+Business Media LLC 2017.
Keywords
- DNA methylation
- Differential expression analysis
- Functional groups
- Gene expression
- Gingiva
- Microarray
- Next-generation sequencing
- Periodontal disease
- Transcriptome
- microRNA