Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue

Sergey A. Telenkov; Digant P. Dave; Shriram Sethuraman; Taner Akkin; Thomas E. Milner

doi:10.1088/0031-9155/49/1/008

Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue

Sergey A. Telenkov, Digant P. Dave, Shriram Sethuraman, Taner Akkin, Thomas E. Milner

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.

Original language	English (US)
Pages (from-to)	111-119
Number of pages	9
Journal	Physics in Medicine and Biology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1088/0031-9155/49/1/008
State	Published - Jan 7 2004

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AU - Milner, Thomas E.

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AB - We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.

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Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue

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