Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development

J. D. Miller; D. Masopust; E. J. Wherry; S. Kaech; G. Silvestri; R. Ahmed

doi:10.2174/1568005054201544

Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development

J. D. Miller, D. Masopust, E. J. Wherry, S. Kaech, G. Silvestri, R. Ahmed

Microbiology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.

Original language	English (US)
Pages (from-to)	121-129
Number of pages	9
Journal	Current Drug Targets - Infectious Disorders
Volume	5
Issue number	2
DOIs	https://doi.org/10.2174/1568005054201544
State	Published - Jun 1 2005

Keywords

CD8 T cells
Differentiation
HIV vaccine
Immune memory
LCMV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development",

abstract = "Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.",

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AU - Kaech, S.

AU - Silvestri, G.

AU - Ahmed, R.

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AB - Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.

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KW - Immune memory

KW - LCMV

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Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development

Abstract

Keywords

UN SDGs

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