Diffusion in bile and its implications on detergency

R. C. Sehlin, E. L. Cussler, D. F. Evans

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Diffusion coefficients of bile salts, lecithin, and cholesterol above the critical micelle concentration have been measured with the diaphragm cell at varying concentrations of bile salts, lecithin, and added electrolyte. The diffusion of the bile salt can be five times faster than that of the solubilized lipids. This is shown not to be an artifact of multicomponent diffusion, but a result of a different transport mechanism of the bile salt. As a consequence, the concentration of bile salt and lipids at the surface of a cholesterol gallstone can differ from those in the bile solution. The effects of this upon growth and dissolution in detergent solutions are discussed.

Original languageEnglish (US)
Pages (from-to)385-396
Number of pages12
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume388
Issue number3
DOIs
StatePublished - Jun 23 1975
Externally publishedYes

Bibliographical note

Funding Information:
This work was partially supported by the National Institute of Arthritis, Metabolic and Digestive Diseases Grant l-ROl-AM-16143. E.L. Cussler and D.F. Evans have Career Development Awards lK04-AM-70461 and 5K4-AM-12972.

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