Dimerization of α-tocopherol in vivo

A. Saari Csallany; H. H. Draper

doi:10.1016/0003-9861(63)90082-1

Dimerization of α-tocopherol in vivo

A. Saari Csallany, H. H. Draper

Food Science and Nutrition

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20 Scopus citations

Abstract

Following administration of d-α-tocopherol-C¹⁴ to rats, a previously uncharacterized metabolite of the vitamin was isolated from the liver. This compound was shown by cochromatography and carrier crystallization to be identical to an oxidation product of α-tocopherol obtained by treatment with alkaline K₃Fe(CN)₆. Evidence is presented that the compound is a dimer of α-tocopherol.

Original language	English (US)
Pages (from-to)	335-337
Number of pages	3
Journal	Archives of Biochemistry and Biophysics
Volume	100
Issue number	2
DOIs	https://doi.org/10.1016/0003-9861(63)90082-1
State	Published - Feb 1963

Bibliographical note

Funding Information:
The synthesis of the compound was achieved by a slight modification of the procedure of Martius and Eilingsfeld (3). d+Tocopherol, 2.0 g., was dissolved in 100 ml. petroleum ether (30-60”) and combined with 40 ml. of 0.2 N NaOH containing 4.0 g. K3Fe(CN) 6. The mixture was shaken for 1 hr. in a water bath at 45°C. After removal of the organic phase, the aqueous phase was washed with two 100-ml. portions of petroleum ether, and the combined ether phases were backwashed five times with 100 ml. water. The petroleum ether was dried over anhydrous NatSOd, and the solvent was re- 1 This investigation was supported by grants from the National Science Foundation (G-21374) and the Muscular Dystrophy Associations of America, Inc.

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title = "Dimerization of α-tocopherol in vivo",

abstract = "Following administration of d-α-tocopherol-C14 to rats, a previously uncharacterized metabolite of the vitamin was isolated from the liver. This compound was shown by cochromatography and carrier crystallization to be identical to an oxidation product of α-tocopherol obtained by treatment with alkaline K3Fe(CN)6. Evidence is presented that the compound is a dimer of α-tocopherol.",

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note = "Funding Information: The synthesis of the compound was achieved by a slight modification of the procedure of Martius and Eilingsfeld (3). d+Tocopherol, 2.0 g., was dissolved in 100 ml. petroleum ether (30-60”) and combined with 40 ml. of 0.2 N NaOH containing 4.0 g. K3Fe(CN) 6. The mixture was shaken for 1 hr. in a water bath at 45°C. After removal of the organic phase, the aqueous phase was washed with two 100-ml. portions of petroleum ether, and the combined ether phases were backwashed five times with 100 ml. water. The petroleum ether was dried over anhydrous NatSOd, and the solvent was re- 1 This investigation was supported by grants from the National Science Foundation (G-21374) and the Muscular Dystrophy Associations of America, Inc.",

year = "1963",

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doi = "10.1016/0003-9861(63)90082-1",

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AU - Draper, H. H.

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N2 - Following administration of d-α-tocopherol-C14 to rats, a previously uncharacterized metabolite of the vitamin was isolated from the liver. This compound was shown by cochromatography and carrier crystallization to be identical to an oxidation product of α-tocopherol obtained by treatment with alkaline K3Fe(CN)6. Evidence is presented that the compound is a dimer of α-tocopherol.

AB - Following administration of d-α-tocopherol-C14 to rats, a previously uncharacterized metabolite of the vitamin was isolated from the liver. This compound was shown by cochromatography and carrier crystallization to be identical to an oxidation product of α-tocopherol obtained by treatment with alkaline K3Fe(CN)6. Evidence is presented that the compound is a dimer of α-tocopherol.

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Dimerization of α-tocopherol in vivo

Abstract

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