Les protéines DING: Propriétés biochimiques, structurales, et capacité à inhiber la réplication du virus VIH-1

Translated title of the contribution: DING proteins, their biochemical and structural properties, and their ability to inhibit HIV-1 replication

Éric Chabriere, Mikael Elias, Julien Hiblot, Ahmed Djeghader, Christian Schwartz, Olivier Rohr, Patrick Masson

Research output: Contribution to journalArticlepeer-review

Abstract

DING proteins comprise an intriguing phosphate-binding protein family present in all animal phyla. Five different DING representatives have been described in humans. Euka-ryotic DING proteins are mostly involved in cellular processes such as cell cycle regulation, and also in pathological process such as rheumatoid arthritis and kidney stone formation. Although these proteins are ubiquitous in eukaryotes, no relevant locus or ORFhasyet been found in sequenced genomes. This lack of sequence information has considerably hampered functional and structural studies of these proteins, and has required the use of novel and original techniques such as ab initio protein sequencing based on a combination of X-ray crystallography and mass spectrometry. Sub-Angstrom structural resolution has elucidated the molecular binding mechanism of phosphate ions by these high-affinity proteins. Immu-nohistochemical studies show that these proteins are present in a wide variety of mouse tissues. Some DING proteins, particularly human phosphate binding protein (HPBP), can inhibit HIV replication. This inhibition takes place at the transcriptional step, which is not targeted by any current antiretroviral drug. Initial studies suggest that HPBP warrants animal testing. This recent discovery opens new possibilities for the treatment of HIV infection.

Translated title of the contributionDING proteins, their biochemical and structural properties, and their ability to inhibit HIV-1 replication
Original languageFrench
Pages (from-to)693-704
Number of pages12
JournalBulletin de l'Academie Nationale de Medecine
Volume196
Issue number3
StatePublished - Mar 1 2012

Keywords

  • HIV
  • Phosphate-binding proteins

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