Direct Methods for α-Methylene Lactone Synthesis Using Itaconic Acid Derivatives

Robert M. Carlson, Alan R. Oyler

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Anions of itaconic acid derivatives [RO2CCHC(=CH2)CO2] are versatile intermediates for the synthesis of α-methylene lactones. The addition of these anionic species to aldehydes or ketones and subsequent lactonization and hydrolysis have been utilized for the synthesis of a variety of compounds including protolichesterinic acid, nephrosterinic acid, and canadensolide.

Original languageEnglish (US)
Pages (from-to)4065-4069
Number of pages5
JournalJournal of Organic Chemistry
Volume41
Issue number26
DOIs
StatePublished - Dec 1 1976

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