TY - JOUR
T1 - Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon
AU - Burstein, R.
AU - Cliffer, K. D.
AU - Giesler, G. J.
PY - 1987
Y1 - 1987
N2 - Somatosensory input to the hypothalamus has been thought to ascend via an indirect, multisynaptic pathway. However, we have antidromically identified nociceptive spinal cord neurons that project directly to the lateral hypothalamus in rats. Retrograde tracers injected into the lateral hypothalamus labeled many spinal neurons bilaterally within the marginal zone, the lateral reticulated area, the lateral spinal nucleus, and the area surrounding the central canal. An anterograde tracer injected into these areas of the spinal cord labeled fibers and terminals in the lateral hypothalamus and, surprisingly, in a number of telencephalic areas. These findings demonstrate a direct somatosensory projection from the spinal cord to the hypothalamus and several telencephalic regions.
AB - Somatosensory input to the hypothalamus has been thought to ascend via an indirect, multisynaptic pathway. However, we have antidromically identified nociceptive spinal cord neurons that project directly to the lateral hypothalamus in rats. Retrograde tracers injected into the lateral hypothalamus labeled many spinal neurons bilaterally within the marginal zone, the lateral reticulated area, the lateral spinal nucleus, and the area surrounding the central canal. An anterograde tracer injected into these areas of the spinal cord labeled fibers and terminals in the lateral hypothalamus and, surprisingly, in a number of telencephalic areas. These findings demonstrate a direct somatosensory projection from the spinal cord to the hypothalamus and several telencephalic regions.
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U2 - 10.1523/jneurosci.07-12-04159.1987
DO - 10.1523/jneurosci.07-12-04159.1987
M3 - Article
C2 - 3694268
AN - SCOPUS:0023514506
SN - 0270-6474
VL - 7
SP - 4159
EP - 4164
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 12
ER -