Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon

R. Burstein, K. D. Cliffer, G. J. Giesler

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

Somatosensory input to the hypothalamus has been thought to ascend via an indirect, multisynaptic pathway. However, we have antidromically identified nociceptive spinal cord neurons that project directly to the lateral hypothalamus in rats. Retrograde tracers injected into the lateral hypothalamus labeled many spinal neurons bilaterally within the marginal zone, the lateral reticulated area, the lateral spinal nucleus, and the area surrounding the central canal. An anterograde tracer injected into these areas of the spinal cord labeled fibers and terminals in the lateral hypothalamus and, surprisingly, in a number of telencephalic areas. These findings demonstrate a direct somatosensory projection from the spinal cord to the hypothalamus and several telencephalic regions.

Original languageEnglish (US)
Pages (from-to)4159-4164
Number of pages6
JournalJournal of Neuroscience
Volume7
Issue number12
DOIs
StatePublished - 1987

Fingerprint

Dive into the research topics of 'Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon'. Together they form a unique fingerprint.

Cite this