Direct stimulation of the transfer of antibiotic resistance by sex pheromones in Streptococcus faecalis

Gary Dunny, Cindee Funk, Jean Adsit

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Clinical isolates of Streptococcus faecalis were examined for plasmid content and plasmid-related traits in order to determine whether such strains carried conjugative antibiotic resistance plasmids whose transfer was stimulated by sex pheromones. A 35-Mdalton tetracycline-resistance plasmid called pCF-10 was identified. pCF-10 carries genes that enable its host cell to clump and to act as a highly effective donor when exposed to sex pheromone preparations from recipients. The genetic background of the host cell markedly affects the expression of the pCF-10 fertility functions. The properties of this plasmid make it a good candidate for a detailed genetic analysis of streptococcal conjugation.

Original languageEnglish (US)
Pages (from-to)270-278
Number of pages9
JournalPlasmid
Volume6
Issue number3
DOIs
StatePublished - Nov 1981

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