Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection

Elise R. Breed, S. Thera Lee, Kristin A. Hogquist

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The development of a self-tolerant and effective T cell receptor repertoire is dependent on interactions coordinated by various antigen presenting cells (APC) within the thymus. T cell receptor–self-peptide–MHC interactions are essential for determining T cell fate, however different cytokine and co-stimulatory signals provided by the diverse APCs within the thymus are also critical. Here, we outline the different localization and functional capabilities of thymic APCs. We also discuss how these distinct APCs work collectively to facilitate the establishment of a diverse T cell receptor repertoire that is tolerant to an array of different self-antigens.

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume84
DOIs
StatePublished - Dec 2018

Bibliographical note

Funding Information:
We thank Katharine Block and Tijana Martinov for their feedback on this manuscript. Research in the Hogquist laboratory is supported by the NIH ( R37 AI39560 and PO1 AI35296 ) and T32 training grant support to ERB ( T32 AI007313 and T32 GM008244 ) and STL ( T32 GM113846 ).

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • Antigen presentation
  • Dendritic cells
  • Selection
  • Thymic epithelial cells
  • Thymus
  • Tolerance

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