Abstract
This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) for Staphylococcus aureus between a common automated system (Vitek 2) and the E-test method in patients with S. aureus bloodstream infections. At an area under the serum concentration time curve (AUC) threshold of 400 mg·h/L, we would have reached the current Infectious Diseases Society of America (IDSA)/American Society of Health System Pharmacists (ASHP)/Society of Infectious Diseases Pharmacists (SIDP) guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data (p < 0.0001). An AUC of 450 mg·h/L or greater was required to achieve 100% target attainment using either Vitek 2 or E-test MIC results.
Original language | English (US) |
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Article number | 34 |
Journal | Antibiotics |
Volume | 5 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2016 |
Bibliographical note
Publisher Copyright:© 2016 by the authors; licensee MDPI, Basel, Switzerland.
Keywords
- MIC
- Staphylococcus aureus
- Susceptibility testing
- Vancomycin