Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence

R. Adron Harris; Hiroaki Yamamoto; Horace H. Loh; E. Leong Way

doi:10.1016/0024-3205(77)90393-9

Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence

R. Adron Harris, Hiroaki Yamamoto, Horace H. Loh, E. Leong Way

Pharmacology

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Abstract

Subcellular localization of ⁴⁵Ca⁺⁺ in brain was determined after intracerebroventricular injection of the isotope in mice. Acute morphine injection selectively depleted ⁴⁵Ca⁺⁺ from synaptic vesicles while chronic morphine treatment increased the ⁴⁵Ca⁺⁺ in vesicular fractions. The elevated vesicular ⁴⁵Ca⁺⁺ found in tolerant-dependent animals rapidly declined during naloxone precipitated abstinence. These effects of morphine on brain Ca⁺⁺ localization are discussed in terms of their possible relationship to neurotransmitter release and tolerance and dependence development.

Original language	English (US)
Pages (from-to)	501-505
Number of pages	5
Journal	Life Sciences
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(77)90393-9
State	Published - Feb 1 1977

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AB - Subcellular localization of 45Ca++ in brain was determined after intracerebroventricular injection of the isotope in mice. Acute morphine injection selectively depleted 45Ca++ from synaptic vesicles while chronic morphine treatment increased the 45Ca++ in vesicular fractions. The elevated vesicular 45Ca++ found in tolerant-dependent animals rapidly declined during naloxone precipitated abstinence. These effects of morphine on brain Ca++ localization are discussed in terms of their possible relationship to neurotransmitter release and tolerance and dependence development.

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Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence

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