Subcellular localization of 45Ca++ in brain was determined after intracerebroventricular injection of the isotope in mice. Acute morphine injection selectively depleted 45Ca++ from synaptic vesicles while chronic morphine treatment increased the 45Ca++ in vesicular fractions. The elevated vesicular 45Ca++ found in tolerant-dependent animals rapidly declined during naloxone precipitated abstinence. These effects of morphine on brain Ca++ localization are discussed in terms of their possible relationship to neurotransmitter release and tolerance and dependence development.
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