Abstract
Sites of DNA synthesis initiation have been detected at the nucleotide level in a yeast origin of bidirectional replication with the use of replication initiation point mapping. The ARS1 origin of Saccharomyces cerevisiae showed a transition from discontinuous to continuous DNA synthesis in an 18-base pair region (nucleotides 828 to 845) from within element B1 toward B2, adjacent to the binding site for the origin recognition complex, the putative initiator protein.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-98 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 279 |
| Issue number | 5347 |
| DOIs | |
| State | Published - Jan 2 1998 |