Spotted cDNA microarrays are emerging as a cost effective tool for the large scale analysis of gene expression. To reveal the patterns of genes expressed within a specific cell essentially responsible for its phenotype, this paper reports our progress in cluster discovery using a newly developed data mining method. The discussion entails: (1) statistical modeling of gene microarray data with a standard finite normal mixture distribution, (2) development of a joint supervised and unsupervised discriminative mining to discover sample clusters in a visual pyramid, and (3) evaluation of the data clusters produced by such scheme with phenotype-known microarray experiments.
|Original language||English (US)|
|Number of pages||10|
|State||Published - 2001|