Disorders of neuromuscular transmission

Georgios E Manousakis

doi:10.1007/978-3-319-67116-1_3

Disorders of neuromuscular transmission

Georgios E Manousakis

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The neuromuscular junction (NMJ) is a specialized structure connecting the motor nerve terminal to the muscle membrane. Dysfunction of the NMJ can occur due to genetic mutations, autoimmune or toxic causes. NMJ disorders are important to recognize because they can lead to severe or life-threatening weakness, and most of them are treatable. A summary of NMJ anatomy and the pathophysiology, clinical presentation, diagnostic evaluation, and treatment of the most common NMJ disorders is presented below.

Original language	English (US)
Title of host publication	Clinical Handbook of Neuromuscular Medicine
Publisher	Springer International Publishing
Pages	45-56
Number of pages	12
ISBN (Electronic)	9783319671161
ISBN (Print)	9783319671154
DOIs	https://doi.org/10.1007/978-3-319-67116-1_3
State	Published - Jan 1 2018

Keywords

Botulism
Lambert-Eaton myasthenic syndrome
Myasthenia gravis
Neuromuscular junction
Thymectomy

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AB - The neuromuscular junction (NMJ) is a specialized structure connecting the motor nerve terminal to the muscle membrane. Dysfunction of the NMJ can occur due to genetic mutations, autoimmune or toxic causes. NMJ disorders are important to recognize because they can lead to severe or life-threatening weakness, and most of them are treatable. A summary of NMJ anatomy and the pathophysiology, clinical presentation, diagnostic evaluation, and treatment of the most common NMJ disorders is presented below.

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KW - Thymectomy

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Disorders of neuromuscular transmission

Abstract

Keywords

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