Disulfide bond formation in peptides.

L. Chen, I. Annis, G. Barany

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The formation of disulfide bridges is often a crucial final stage in peptide synthesis. There is compelling evidence that the disulfide pattern can be critical in the folding and structural stabilization of many natural peptide and protein sequences, while the artificial introduction of disulfide bridges into natural or designed peptides may often improve biological activities/specificities and stabilities. This unit provides a highly selective, albeit state-of-the-art, menu of procedures that can be performed to establish intramolecular or intermolecular disulfide bridges in targets of varying complexities.

Original languageEnglish (US)
Pages (from-to)Unit18.6
JournalCurrent protocols in protein science / editorial board, John E. Coligan ... [et al.]
VolumeChapter 18
StatePublished - May 2001


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