Diverse roles of integrins in human T lymphocyte biology

Yuko J. Miyamoto, Bernard F. Andruss, Jason S. Mitchell, Matthew J. Billard, Bradley W. McIntyre

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

T lymphocytes are the primary cells responsible for maintaining the immune system. There are many intricate mechanisms involved in the regulation oft cells and the integrin family of adhesive surface proteins plays a pivitol role in the control of T lymphocyte activation and functions. Integrins are heterodimeric transmembrane proteins that are not merely adhesion molecules but also function in T cell coactivation by providing a scaffold for signaling and cytoskeletal proteins that are adept at transmitting signals from the inside of the cell to the outside ("inside-out signaling") or from the outside of the cell to the inside ("outside-in signaling"). The signaling property of integrins allows for rapid responses to changes in the microenviroment of the lymphocyte. Therefore, whether the T cell needs to adhere or detach, integrins can quickly accommodate either state of the cell. Once cells are guided to sites of infection, inflammation, or antigen presentation, integrins can also participate in the initiation, maintenance, or termination of the response. This review will focus on the aspects of integrin-mediated T cell coactivation, affinity and avidity control of integrins, signaling molecules involved with integrins, association of integrins in lipid microdomains, and negative regulation of integrins.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalImmunologic Research
Volume27
Issue number1
DOIs
StatePublished - 2003

Keywords

  • Costimulation
  • Integrin
  • Microdomains
  • Signaling
  • T lymphocytes
  • Transdominant suppression

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