Diverse roles of SIRT1 in cancer biology and lipid metabolism

Glenn E. Simmons, Wendy M. Pruitt, Kevin Pruitt

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

SIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in response to diverse physiological stress. Interestingly, many of the metabolic pathways that are influenced by SIRT1 are also altered in tumor development. Not only does SIRT1 have the potential to regulate oncogenic factors, it also orchestrates many aspects of metabolism and lipid regulation and recent reports are beginning to connect these areas. SIRT1 influences pathways that provide an alternative means of deriving energy (such as fatty acid oxidation and gluconeogenesis) when a cell encounters nutritive stress, and can therefore lead to altered lipid metabolism in various pathophysiological contexts. This review helps to show the various connections between SIRT1 and major pathways in cellular metabolism and the consequence of SIRT1 deregulation on carcinogenesis and lipid metabolism.

Original languageEnglish (US)
Pages (from-to)950-965
Number of pages16
JournalInternational journal of molecular sciences
Volume16
Issue number1
DOIs
StatePublished - Jan 5 2015

Keywords

  • Cancer
  • Fatty acid
  • Lipids
  • Lipolysis
  • Metabolism
  • SIRT1
  • Sirtuin
  • Steatosis
  • Sterol regulatory element-binding protein (SREBP)

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