DNA confinement drives uncoating of the HIV Virus

I. Rouzina, R. Bruinsma

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the confinement force exerted on the capsid wall porduced to the double-stranded DNA generated by reverse transcriptase.

Original languageEnglish (US)
Pages (from-to)1745-1754
Number of pages10
JournalEuropean Physical Journal: Special Topics
Volume223
Issue number9
DOIs
StatePublished - Sep 1 2014

Bibliographical note

Funding Information:
IR acknowledges support from NIH Grant GM065056 and Professors Karin Musier-Forsyth, Alan Rein and Judith Levin for support and discussions. RFB acknowledges support by the Institute of Advanced Studies of the TUM and by the NSF under DMR Grant 1006128. We thank A. Grosberg for helpful discussion.

Publisher Copyright:
© 2014, EDP Sciences and Springer.

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