DNA damage response and repair: Insights into strategies for radiation sensitization of gliomas

Santosh Kesari, Sunil J. Advani, Joshua D. Lawson, Kristopher T. Kahle, Kimberly Ng, Bob Carter, Clark C. Chen

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The incorporation of radiotherapy into multimodality treatment plans has led to significant improvements in glioma patient survival. However, local recurrence from glioma resistance to ionizing radiation remains a therapeutic challenge. The tumoricidal effect of radiation therapy is largely attributed to the induction of dsDNA breaks (DSBs). In the past decade, there have been tremendous strides in understanding the molecular mechanisms underlying DSB repair. The identification of gene products required for DSB repair has provided novel therapeutic targets. Recent studies revealed that many US FDA-approved cancer agents inhibit DSB repair by interacting with repair proteins. This article will aim to provide discussion of DSB repair mechanisms to provide molecular targets for radiation sensitization of gliomas and a discussion of FDA-approved cancer therapies that modulate DSB repair to highlight opportunities for combination therapy with radiotherapy for glioma therapy.

Original languageEnglish (US)
Pages (from-to)1335-1346
Number of pages12
JournalFuture Oncology
Issue number11
StatePublished - Nov 2011


  • DNA damage response
  • DNA double strand break repair
  • chemotherapy
  • glioblastoma
  • radiosensitization
  • radiotherapy


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