Abstract
We present a theoretical study of the electrophoresis of DNA through a periodic array of narrow slits and deep wells (a nanofilter). We focus on the transport of short DNA under strong fields, showing that longer molecules travel faster due to a new mechanism "torque-assisted escape". This new prediction can lead to enhanced nanofluidic separations of DNA.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
| Editors | Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 997-999 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806407 |
| State | Published - 2007 |
| Event | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France Duration: Oct 7 2007 → Oct 11 2007 |
Publication series
| Name | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
|---|
Conference
| Conference | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
|---|---|
| Country | France |
| City | Paris |
| Period | 10/7/07 → 10/11/07 |
Bibliographical note
Funding Information:.D. and . . acknowledge the support of the U N Bioinformatics ummer Institute. This work was carried out in part using computing resources at the University of innesota upercomputing Institute. We are grateful to Prof. atish ,umar and Nazish oda for useful discussions on Brownian dynamics.
Keywords
- DNA Electrophoresis
- Nanofilters
- Nanofluidics
- Non-equilibrium transport