DNA nanofiltration at high electric fields

Nabil Laachi, Carmelo Declet, Christina Matson, Kevin D. Dorfman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a theoretical study of the electrophoresis of DNA through a periodic array of narrow slits and deep wells (a nanofilter). We focus on the transport of short DNA under strong fields, showing that longer molecules travel faster due to a new mechanism "torque-assisted escape". This new prediction can lead to enhanced nanofluidic separations of DNA.

Original languageEnglish (US)
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages997-999
Number of pages3
ISBN (Electronic)9780979806407
StatePublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: Oct 7 2007Oct 11 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period10/7/0710/11/07

Bibliographical note

Funding Information:
.D. and . . acknowledge the support of the U N Bioinformatics ummer Institute. This work was carried out in part using computing resources at the University of innesota upercomputing Institute. We are grateful to Prof. atish ,umar and Nazish oda for useful discussions on Brownian dynamics.

Keywords

  • DNA Electrophoresis
  • Nanofilters
  • Nanofluidics
  • Non-equilibrium transport

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